This tool helps estimate testosterone and estradiol levels based on user-specific TRT protocols. It simulates hormone levels over time and provides potential risk indicators for hemoglobin elevation, prostate health, cholesterol impact, and liver strain. Ideal for monitoring and optimizing testosterone cypionate therapy cycles.
Testosterone Cypionate therapy is influenced by several biological and lifestyle factors. The dose and frequency of injections play a major role in how testosterone levels fluctuate in the bloodstream. Higher concentrations and more frequent injections typically result in elevated serum testosterone, which in turn can accelerate conversion to estradiol—a process heavily influenced by aromatase activity.
Body fat percentage is a critical factor in testosterone metabolism. Fat cells contain aromatase, the enzyme responsible for converting testosterone into estradiol (a form of estrogen). Higher body fat leads to more conversion, which may increase the risk of estrogen-related side effects such as gynecomastia, water retention, and mood swings. Meanwhile, total body weight affects distribution volume, slightly modulating the rate at which testosterone disperses through the body.
The timing of your lab work in relation to your injection day is vital. Testosterone levels peak within 24–48 hours post-injection and taper off gradually. Knowing when your blood was drawn helps contextualize the results—whether you're seeing peak, trough, or average levels. Your last known lab value is used as the baseline for this simulation and helps calibrate the hormonal curve visualized in the graph.
Long-term TRT usage and age both correlate with potential side effects. Prolonged exposure can lead to elevated red blood cell count (hemoglobin and hematocrit), increasing the risk of cardiovascular strain. Age also plays a role in prostate health and cholesterol metabolism, both of which are monitored indicators in this calculator. Older individuals may require closer supervision to balance therapeutic benefits with risk management.
Total Testosterone: Calculated by simulating peaks and decay curves using the known half-life of testosterone cypionate (approximately 8 days). Injections are summed over time to reflect realistic fluctuations.
Free Testosterone: Estimated from total testosterone using a typical percentage (e.g., 2-3%) depending on SHBG assumption and user factors.
Estradiol Levels: Estimated as a conversion percentage of total testosterone, with a multiplier that increases if body fat is above 20%, reflecting higher aromatase activity.
Hemoglobin Risk: Based on cumulative exposure to supraphysiologic testosterone levels (>1000 ng/dL) over time. The longer and higher the exposure, the greater the projected risk.
Cholesterol Impact: High testosterone can reduce HDL cholesterol. The tool estimates this risk by accounting for dose, frequency, and duration of TRT.